Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis
نویسندگان
چکیده
منابع مشابه
Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Nonalcoholic fatty liver disease (NAFLD) is a well-recognized form of chronic liver disease affecting both children and adults that has gained increased recognition. Recently NAFLD has been associated with insulin resistance and its incidence and prevalence is likely increasing, paralleling the rise in obesity and diabetes mellitus in the United States. The article includes current thoughts on ...
متن کاملFatty Liver and Nonalcoholic Steatohepatitis
Background: Fatty liver (FL) is the most common liver disease but its clinical significance remains elusive. Nonalcoholic steatohepatitis (NASH) is increasingly recognized as a cause of liver failure, sometimes recurring following transplantation. Recent data on both conditions are critically reviewed. Methods: A Medline search of the medical literature (1990 to September 1998) and cross-refere...
متن کاملNonalcoholic steatohepatitis (NASH) with diabetes: predictors of liver fibrosis.
INTRODUCTION Nonalcoholic steatohepatitis (NASH) is common cause of chronic liver disease strongly associated with insulin resistance leading to fibrosis. No factors that determine increasing fibrosis have been well recognized. Liver biopsy is considered as gold standard for diagnosis and prognosis of this disease. AIM To identify independent predictive factors of liver fibrosis in patients o...
متن کاملThe vitamin E reduces liver lipoperoxidation and fibrosis in a model of nonalcoholic steatohepatitis.
CONTEXT No effective treatment is available for nonalcoholic steatohepatitis in nowadays. OBJECTIVES To develop a model of nonalcoholic steatohepatitis induced by a methionine and choline deficient diet, as well as to evaluate the role of metformin, vitamin E and simvastatin in the nonalcoholic steatohepatitis progression. METHODS The study analyzed prospectively 50 Wistar rats for a 90-day...
متن کاملRisk of nonalcoholic steatohepatitis and fibrosis in patients with nonalcoholic fatty liver disease and low visceral adiposity.
BACKGROUND & AIMS Increased visceral adiposity is considered the hallmark of the metabolic syndrome, whose hepatic manifestation is nonalcoholic fatty liver disease (NAFLD), although a subset of patients does not have visceral obesity. Our study aimed to compare metabolic alterations and liver damage in patients with NAFLD with and without visceral obesity. METHODS Four hundred and thirty one...
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ژورنال
عنوان ژورنال: JAMA Internal Medicine
سال: 2017
ISSN: 2168-6106
DOI: 10.1001/jamainternmed.2016.9607